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- The Walker A and Walker B motifs are protein sequence motifs, known to have highly conserved three-dimensional structures. These were first reported in ATP-binding proteins by Walker and co-workers in 1982.Of the two motifs, the A motif is the main "P-loop" responsible for binding phosphate, while the B motif is a much less conserved downstream region. The P-loop is best known for its presence in ATP- and GTP-binding proteins, and is also found in a variety of proteins with phosphorylated substrates. Major lineages include: RecA and rotor ATP synthase / ATPases (α and β subunits). Nucleic acid-dependent ATPases: helicases, Swi2, and PhoH (InterPro: IPR003714) AAA proteins STAND NTPases including MJ, PH, AP, and NACHT ATPases ABC-PilT ATPases Nucleotide kinases (InterPro: IPR000850) G domain proteins: G-proteins (transducin), myosin.
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"walker motifs." Anagrams.net. STANDS4 LLC, 2024. Web. 4 May 2024. <https://www.anagrams.net/walker%20motifs>.
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