Any good anagrams for locus control region?

Locus control regions are defined by their ability to enhance the expression of linked genes to physiological levels in a tissue-specific and copy number-dependent manner at ectopic chromatin sites. The concept derives from the idea that developmental and cell lineage-specific regulation of gene expression relies not only on gene-proximal elements such as promoters, enhancers, and silencers, but also on long-range interactions of various cis-regulatory elements and dynamic chromatin alterations. The LCR was identified over 20 years ago. In transgenic mouse studies it was determined that the LCR was required for normal regulation of beta-globin gene expression. Several models exist for how the LCR exerts its effects on transcription from a distance.

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