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Histone deacetylases (EC 3.5.1.98, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins.

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histomorphologically, histomorphology, histon, histonal, histone, histonomy, histopathologic, histopathological, histopathologist, histopathology

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"histone deacetylases." Anagrams.net. STANDS4 LLC, 2024. Web. 19 May 2024. <https://www.anagrams.net/histone%20deacetylases>.

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