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- Niacin, also known as nicotinic acid, is an organic compound and a form of vitamin B3, an essential human nutrient. It can be manufactured by plants and animals from the amino acid tryptophan. Niacin is obtained in the diet from a variety of whole and processed foods, with highest contents in fortified packaged foods, meat, poultry, red fish such as tuna and salmon, lesser amounts in nuts, legumes and seeds. Niacin as a dietary supplement is used to treat pellagra, a disease caused by niacin deficiency. Signs and symptoms of pellagra include skin and mouth lesions, anemia, headaches, and tiredness. Many countries mandate its addition to wheat flour or other food grains, thereby reducing the risk of pellagra.The amide derivative nicotinamide (niacinamide) is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP+). Although niacin and nicotinamide are identical in their vitamin activity, nicotinamide does not have the same pharmacological, lipid-modifying effects or side effects as niacin, i.e., when niacin takes on the -amide group, it does not reduce cholesterol nor cause flushing. Nicotinamide is recommended as a treatment for niacin deficiency because it can be administered in remedial amounts without causing the flushing, considered an adverse effect.Niacin is also a prescription medication. Amounts far in excess of the recommended dietary intake for vitamin functions will lower blood triglycerides and low density lipoprotein cholesterol (LDL-C), and raise blood high density lipoprotein cholesterol (HDL-C, often referred to as "good" cholesterol). There are two forms: immediate-release and sustained-release niacin. Initial prescription amounts are 500 mg/day, increased over time until a therapeutic effect is achieved. Immediate-release doses can be as high as 3,000 mg/day; sustained-release as high as 2,000 mg/day. Despite the proven lipid changes, niacin has not been found useful for decreasing the risk of cardiovascular disease in those already on a statin. A 2010 review had concluded that niacin was effective as a mono-therapy, but a 2017 review incorporating twice as many trials concluded that prescription niacin, while affecting lipid levels, did not reduce all-cause mortality, cardiovascular mortality, myocardial infarctions, nor fatal or non-fatal strokes. Prescription niacin was shown to cause hepatotoxicity and increase risk of type 2 diabetes. Niacin prescriptions in the U.S. had peaked in 2009, at 9.4 million, declining to 800 thousand by 2020.Niacin has the formula C6H5NO2 and belongs to the group of the pyridinecarboxylic acids. As the precursor for nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate, niacin is involved in DNA repair.
- ripen gall
- ripal glen
- rip langle
- ringle pal
- ringle lap
- ringle alp
- ringe pall
- ring lapel
- rile plang
- rigel plan
- replan gil
- repin gall
- relap ling
- rel paling
- reign pall
- regnal lip
- regin pall
- regill pan
- regill nap
- raping ell
- rap lingel
- aln pilger
- lan pilger
- alp linger
- alp ringle
- pal linger
- pal ringle
- lap linger
- lap ringle
- lar pingle
- nap regill
- nap giller
- nap grille
- pan regill
- pan giller
- pan grille
- par lingel
- gen pillar
- gil replan
- gil planer
- gil parnel
- ell raping
- ell paring
- gean prill
- agen prill
- gaen prill
- gena prill
- gane prill
- nig pellar
- ing pellar
- gin pellar
- ler paling
- lip largen
- lip angler
- lip regnal
- lip rangle
- lip arleng
- lip garnel
- gall piner
- gall repin
- gall ripen
- gall prine
- nepa grill
- nape grill
- pane grill
- pean grill
- neap grill
- nip galler
- pin galler
- galp liner
- pir langle
- pall ringe
- pall regin
- pall reign
- pall grein
- pall nigre
- pall inger
- plan rigel
- glen april
- glen pilar
- glen ripal
- pile gnarl
- legal pirn
- gill paren
- gill arpen
- lire plang
- lier plang
- genal pirl
- glean pirl
- angle pirl
- angel pirl
- galen pirl
- agnel pirl
- lagen pirl
- ling paler
- ling relap
- ling perla
- ling lepra
- ling parle
- ling pearl
- ling parel
- nell graip
- pell grain
- pell agrin
- girl nepal
- girl alpen
- girl plane
- girl panel
- girl penal
- ping aller
- range pill
- anger pill
- grane pill
- areng pill
- grin lapel
- girn lapel
- rip nag ell
- rip len lag
- rip len gal
- rip leg lan
- rip leg aln
- rip lan gel
- rip gen all
- rip gell an
- rip gel aln
- rip gan ell
- rill peg an
- rig pen all
- rig pell an
- rig pan ell
- rig pal len
- rig nep all
- rig nap ell
- rig len lap
- rig len alp
- rep nil lag
- rep nil gal
- rep nig all
- rep nag ill
- rep lin lag
- rep lin gal
- rep lan gil
- rep ing all
- rep in gall
- rep ill gan
- rep gin all
- rep gill an
- rep gil aln
- rel pin lag
- rel pin gal
- rel pig lan
- rel pig aln
- rel pan gil
- rel pal nig
- rel pal ing
- rel pal gin
- rel nip lag
- rel nip gal
- rel nil gap
- rel nig lap
- rel nig alp
- rel nap gil
- rel nag lip
- rel lip gan
- rel lin gap
- rel lap ing
- rel lap gin
- rel lan gip
- rel ing alp
- rel in galp
- rel gip aln
- rel gin alp
- reg pin all
- reg pill an
- reg pan ill
- reg pall in
- reg pal nil
- reg pal lin
- reg nip all
- reg nil lap
- reg nil alp
- reg nap ill
- reg lip lan
- reg lip aln
- reg lin lap
- reg lin alp
- rap nil leg
- rap nil gel
- rap nig ell
- rap lin leg
- rap lin gel
- rap len gil
- rap ing ell
- rap in gell
- rap ill gen
- rap gin ell
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"pellagrin." Anagrams.net. STANDS4 LLC, 2024. Web. 23 Apr. 2024. <https://www.anagrams.net/pellagrin>.
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