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Margherita de L'Épine (also Francesca Margherita de l'Épine; c. 1680 – 8 August 1746, London) was an Italian soprano of the Baroque era. She was among the most popular and successful of London's female singers in the years just before and after Italian opera became introduced to the city. Today, she is best remembered for her performances in the operas of George Frideric Handel, and her longstanding association with the composer Johann Pepusch, whom it seems she married around 1718.

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