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A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).

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"25-hydroxyvitamin d3 1-alpha-hydroxylase." Anagrams.net. STANDS4 LLC, 2024. Web. 28 Mar. 2024. <https://www.anagrams.net/25-hydroxyvitamin%20d3%201-alpha-hydroxylase>.

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